Anti-myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder (MOGAD) in a Pediatric Patient with Rare Presentation of a Cerebellar Tumefactive Lesion

Objective NA. Background Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have been commonly associated with optic neuritis, myelitis, and acute disseminated encephalomyelitis but rarely tumefactive lesions, especially in children. We report a young child MOGAD presenting cerebellar demyelinating lesion . Design/Methods A retrospective chart review Results 3-year-old developmentally appropriate boy fever for five days prior presented gait changes self-resolved seizure lasting less than 5 minutes. Neurologic examination showed abnormal finger to nose on the left side, weakness of lower extremity an ataxic gait. The differential at time was Todd's paralysis versus intracranial process. MRI non-enhancing, ill-defined T2 hyperintense mass effect within cerebellum concerning tumor, abscess, or demyelination. On EEG, lack well sustained modulated posterior dominant rhythm well-developed anterior gradient, moderate background slowing seen. Cerebrospinal fluid 8 white blood cells, 0 red 55 mg/dl glucose, 31 protein, 0.61 IgG index, oligoclonal bands. Mayo Clinic cell-based assay detected anti-MOG antibody serum titer 1:100. Neurological symptoms gradually improved after steroid pulse therapy. Conclusions This highlights novel spectrum radiologic manifestations pediatric patients should always be considered diagnosis lesions.